On 9 September 2021 President Biden issued an executive order (found here) requiring mandatory COVID vaccinations for all federal employees.

For further explanation, please see Axios: Biden mandates COVID vaccines for federal workers, with no option for testing. Federal employees have 75 days from when the executive order was signed to get fully vaccinated, with the only exceptions being medical or religious accommodation. Those who fail to comply face discipline by their agencies up to and including termination.

For more information please see Federal News Network: Biden will now require vaccines for all federal employees via new executive order

This question resolves on 23 November 2021, which is 75 days after the executive order.

By 23 November 2021 will the US Supreme Court overturn any part of President Biden's executive order requiring federal workers to be vaccinated against COVID-19?

This question resolves as positive if the United State Supreme Court rules by 23 November 2021 that any part of President Biden's executive order violates any part of the US Constitution. If it does not, the question will resolve negative. If the Court decides on any aspect of this case without addressing any issues of constitutionality, the question will resolve negative.