According to Satoshi's claimed birth date, it will have been 100 years since zir birth in 2075-04-05 (source: Satoshi Nakamoto — Wikipedia).
We don't know for sure which Bitcoins belong to Satoshi Nakamoto, but the addresses ze owns have been estimated in The Well Deserved Fortune of Satoshi Nakamoto, Bitcoin creator, Visionary and Genius which amount to about 1 million Bitcoins (although another group argues that only ~60-70% of those are zirs: Satoshi’s 1 Million Bitcoin Haul Could Be Smaller Than First Thought). None of those Bitcoins have changed wallets since 2010. As of 2020-02-24, they are currently worth ~10 billion USD.
Will any bitcoins belonging to Satoshi Nakamoto be spent by April 5, 2075?
This question will resolve positively if any bitcoin known to belong to Satoshi Nakamoto's original wallet addresses have been transferred, according to credible media reports.
If any of the coins are spent in a way that's widely known to have been a hack, this will not count. If Satoshi Nakamoto gave zir bitcoins to someone else who then spend them, this will qualify for resolution. Any transactions in any amount of bitcoin will qualify for resolution.