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Will NAD+ boosters be shown in a systematic review to increase human lifespan by >=5% by 2030?

Question

Long-term supplementation of NAD+ boosters such as Nicotinamide Riboside and Nicotinamide Mononucleotide have been demonstrated to increase lifespan in animal models.

Human clinical trials are ongoing, with published papers demonstrating:

  • Safety and increase in NAD+ levels. (1,2)
  • Insulin sensitivity unchanged. (1)
  • Cardiac biomarkers seem to improve. (3)

Will a systematic review of human trials conclude by 2030 that NAD+ boosting is effective in increasing human lifespan by >5%?

This question will resolve positive if at any point until 2030 a systematic review of clinical trials of NAD+ boosting will explicitly mention a lifespan improvement of at least 5% in humans. (results in animal models or lifespan estimation based on results in treatment of diseases are not enough for positive resolution)

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