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Efficacy confirmation of a new Alzheimer's treatment protocol?

In September 2014 a paper published in the journal Aging made a remarkable claim: A treatment for Alzheimer's disease reversed cognitive decline, allowing some people with early stages of the disease to return to work. The study stressed that more extensive investigation into the treatment, called "Metabolic Enhancement for Neurodegeneration" or MEND was needed.

In June 2016, a further study was published, also in Aging, that followed up on the original cohort of 10 patients and included objective measures of cognitive and metabolic function that demonstrated clear improvement using the MEND protocol.

Instead of directly treating the molecular underpinnings of Alzheimer's disease, MEND treats the metabolic and inflammatory symptoms of the disease. The treatment regimen includes a low glycemic diet, stress reduction, and aids to better sleep, as well as vitamins and other products like fish oil and coconut oil. The regimen's goal was to improve metabolic function and reduce inflammation.

All ten patients displayed some cognitive improvement, with some noted as "Marked" or "significant" improvement. If proven out, MEND could represent a significant advance in the ongoing fight against Alzheimer's and dementia, potentially reducing the costs associated with caring for such conditions in an aging population.

So far, however, the MEND protocol has only been carried out in a single cohort and administered by a single research group.

Will MEND be independently replicated by 2025?

This question will resolve as positive if a research group independent of UCLA's Buck Institute for Research on Aging publishes in a reputable journal results of a MEND implementation in a completely separate cohort of patients that shows similar magnitudes of cognitive improvement on or before January 1, 2025.

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