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In the year ending in November 2nd, 2020, will a novel regenerative medicine‐based‐therapy induce excess structural regeneration of digits in rodents?
A digit is the finger or toe of land vertebrates, the skeleton of which consists of small bones called phalanges. The tips of the digits are usually protected keratinous structures (claws, in the case of mice) which are also used for defence or manipulation. Digits are numbered one through five, beginning with the inside digit (thumb) when the palm (paw) is face downward (Encyclopædia Britannica).
The fingertip is the only part of the human limb that is regeneration‐competent (Dolan et al., 2018). The regenerating mouse digit tip has emerged as a model to study a clinically relevant regenerative response. According to (Dolan et al., 2018), this is for good reason:
Studies of digit tip regeneration have identified critical components of the regenerative response, and how an understanding of endogenous regeneration can lead to expanding the regenerative capabilities of nonregenerative amputation wounds. Such studies demonstrate that regeneration‐incompetent wounds can respond to treatment with individual morphogenetic agents by initiating a multi‐tissue response that culminates in structural regeneration.
In the year ending in November 2nd, 2020, will a novel regenerative medicine‐based‐therapy induce excess structural regeneration of digits in mice or rats (i.e. in excess of endogenous regeneration)?
This question resolves positively if results that provide strong evidence of the efficacy of the medicine‐based‐therapy induce excess structural regeneration digits in mice or rats are published in a reputable journal. The regenerative medicine‐based‐therapy must be "novel" in the sense of having not been previously applied to in vivo studies of regenerative response in rodent models. "Strong" evidence includes findings that are statistically significant at a level of 5%, amongst other criteria decided by an admin.
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